| Biochem/physiol Actions | Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1. |
| Protocols & Applications | Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information |
Properties
| biological source | from Streptomyces hygroscopicus |
| sterility | 0.2 μm filtered |
| assay | ≥95% (HPLC) |
| concentration | 2.5 mg/mL in DMSO (2.74 mM) |
| EQP level | Premium |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
| WGK Germany | 1 |
| UEL | 42.00% |
| LEL | 3.50% |
| Flash Point(F) | 189 °F |
| Flash Point(C) | 87 °C |
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